Providence offers rare new trials for solid tumors and lung cancer
In this Article:
- The goal of this two-arm study is to evaluate the maximum tolerated dose (MTD) or maximum administered dose (MAD), which will determine the recommended dose for a phase II trial. Additionally, the study will evaluate the safety, tolerability and effects on the body and clinical activity of IO-108 alone and with pembrolizumab.
- Researchers will evaluate sapanisertib, a targeted therapy, in a study that includes 30 patients with NFE2L2 mutations in their cancer and 20 patients whose cancer does not have the NFE2L2 mutation. Each group will be randomized 1:1 to one of two doses of sapanisertib and schedules for administering the medication.
- In October 2022, the Food and Drug Administration granted a fast-track designation to sapanisertib for use as a potential therapy in patients with unresected or metastatic sqNSCLC, and whose tumors have an NRF2 mutation.